In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 56423-63-3, name is 2-Bromopyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Bromopyrazine
To a reaction flask were added compound 5 (200 mg, 0.392 mmol), 2-bromopyrazine (92.9 mg, 0.588 mmol),Pd(dppf)Cl2 (32 mg, 0.02 mmol) and sodium carbonate (126 mg, 1.18 mmol), 2 mL glycol dimethyl ether and 0.4 mLwater were added, bubbled with nitrogen gas for 10 minutes, heated to 120 C in microwave and reacted for 0.5 hour.After TLC detected the reaction was complete, the reaction was concentrated, purified by silica gel column chromatographyto afford 83 mg of a product, yield: 46%. LC-MS(APCI): m/z = 462.1 (M+1)+; 1H NMR (400 MHz, DMSO) delta 10.23(s, 1H), 8.87 – 8.79 (m, 2H), 8.76 – 8.70 (m, 1H), 8.63 (d, J = 2.5 Hz, 1H), 8.21 (d, J = 2.3 Hz, 1H), 7.87 (d, J = 9.1 Hz,2H), 7.34 (d, J = 8.9 Hz, 2H), 4.87 (d, J = 3.3 Hz, 1H), 4.21 (s, 1H), 3.41 (dd, J = 17.1, 10.5 Hz, 1H), 3.21 (dd, J = 11.3,4.5 Hz, 2H), 2.85 (d, J= 11.6 Hz, 1H), 1.86 (dd, J = 8.7, 4.1 Hz, 1H), 1.75 (s, 1H).
The synthetic route of 56423-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Targetrx, Inc.; WANG, Yihan; ZHAO, Jiuyang; AL, Yixin; (55 pag.)EP3553056; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem