These common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H3Br2N3
Step 3 4-(5-Bromo-iotamiotadazo[l 2-a]pyraziotan-8-ylamiotano)-2-methoxy-N-(6-methylpyriotadiotan-3-ylmethyl) benzamide[00367] 5,8-dibromoimidazo[l,2-a]pyrazme (285 mg, 1 03 mmol) and 4-ammo-2-methoxy-/V-[(6-methylpy?dm-3-yl)methyl]benzamide (280 mg, 1 03 mmol) are stirred in 1PrOH (5 mL) and HBr (48% aq , 380 muL) is added The mixture is heated at reflux for 24 hours The cooled suspension is poured into NaHCO3 (sat aq , 25 mL) and water (25 mL) and extracted with CHCI3 (3 x 40 mL) The extracts are dried over MgStheta4 and evaporated The residue is purified by column chromatography, elutmg with 10% – 20% DCM/MeOH to afford the title compound as a pale yellow solid (200 mg, 0 43 mmol)
The synthetic route of 5,8-Dibromoimidazo[1,2-a]pyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem