Related Products of 91476-80-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 91476-80-1, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.
5,6,7,8-Tetrahydroimidazo[1 ,2-a]pyrazine (0.099 g, 0.804 mmol) was suspended in dichloromethane (DCM) (8 ml). Triethylamine (0.123 ml_, 0.884 mmol) and 2-chloro- 3-(trifluoromethyl)benzoyl chloride (0.195 g, 0.804 mmol) were added and the mixture was stirred at room temperature for 5 hours. The reaction mixture was concentrated in vacuo, the residue dissolved in 1 :1 DMSO/MeOH and purified by mass-directed automated preparative HPLC. Product fractions were concentrated in vacuo to yield an orange gum. This was partitioned between DCM (10ml) and saturated aqueous sodium bicarbonate (4ml) and the organic layer separated. This was concentrated in vacuo to yield 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}- 5,6,7,8-tetrahydroimidazo[1 ,2-a]pyrazine (0.131 g, 0.397 mmol, 49.4 % yield) as a yellow gum. LC/MS [M+H]+ = 330, retention time = 1.02 minutes (5 minute method).
The chemical industry reduces the impact on the environment during synthesis 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALL, Ian David; WALTER, Daryl Simon; WO2010/125101; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem