Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6863-74-7, name is 6-Chloropyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., Safety of 6-Chloropyrazine-2-carbonitrile
To a suspension of Raney-Ni (307 mg, 3.59 mmol,) in EtOH (20 ml_) was added 6- chloropyrazine-2-carbonitrile (1 .00 g, 7.17 mmol,) and terf-butoxycarbonyl tert-butyl carbonate (1 .72 g, 7.88 mmol), then the reaction mixture was stirred at room temperature under H2(45psi) for 16 hours. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography (eluention with 0-10% Ethyl acetatertetroleum ether gradient) to give tert-butyl N-[(6-chloropyrazin-2-yl)methyl]carbamate (1 .05 g).
The synthetic route of 6863-74-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (270 pag.)WO2018/7249; (2018); A1;,
Pyrazine – Wikipedia,
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