Related Products of 912773-21-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 912773-21-8, name is 2-Bromo-5-chloropyrazine, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 2-bromo-5-chloro-pyrazine (4 g, 20.68 mmol), 2-benzyloxy-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridine (7.08 g, 22.75 mmol), CS2CO3 (l3.47g, 4l.36mmol) and Pd(dppf)Cl2 (1.51 g, 2.07 mmol) in l,4-dioxane (50mL) and water (lOmL) was stirred at 50 C under N2 for 3 hours. After cooling to room temperature, the mixture was filtered and concentrated to give a residue. To the residue was added water (100 mL), extracted with EtOAc (150 mL x 2). The combined organic phase was washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated to give the crude product. The crude product was filtered through silica gel (~ 50 g) and eluted with DCM (150 mL x 3). The filtrate was concentrated to give the impure product. The impure product was triturated from /-Pi O (15 mL) to give the product of (4 g, 13.44 mmol, 65% yield) as a solid. LCMS Rt= 1.03 min in 1.5 min chromatography, 5-95AB, MS ESI calcd. for Ci6H13ClN30 [M+H]+298.1, found 297.9.
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-5-chloropyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; MARTINEZ BOTELLA, Gabriel; REDDY, Kiran; WITTMANN, Marion; (0 pag.)WO2019/232209; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem