Related Products of 54608-52-5, These common heterocyclic compound, 54608-52-5, name is 2-Hydrazinopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of methyl 3 -(4-methanesulfonylphenyl)-2-methyl-3 -oxopropanoate (1 g, 3.7 mmol) and 2-hydrazinylpyrazine (0.41 g, 3.7 mmol) in ethanol (15 mL) was heated in a pressure tube for 2 hours at 70 C, followed by 72 hours at about 25 C and 24 hours at 70 C. The reaction mixture was cooled to about 25 C and the solvent was removed under reduced pressure to afford a brown oil. Thecrude oil was purified by silica gel chromatography eluting in 0-30 % methanol: ethyl acetate, followed by an SCX-2 cartridge eluting in methanol to give the title compound as a yellow solid (40 mg, 3 %). LC-MS tR = 0.95 mi [M+H] = 331, ?H NMR (500 MHz, Methanol-d4) 9.56 (s, 1H), 8.59 – 8.50 (m, 2H), 8.14 (d, J = 8.5 Hz, 2H), 8.05 (d, J = 8.5 Hz, 2H), 3.22 (s, 3H), 2.16 (s, 3H).
The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CARDIOXYL PHARMACEUTICALS, INC.; THE JOHNS HOPKINS UNIVERSITY; KALISH, Vincent, J.; BROOKFIELD, Frederick, A.; COURTNEY, Stephen, M.; FROST, Lisa, M.; TOSCANO, John, P.; GUTHRIE, Daryl, A.; NORTH, Carl, L.; (442 pag.)WO2015/183839; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem