Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione
Under air, a test tube was charged with 2,3-dichlorodiazaphthalic anhydride (400mg, 1.826mmol) and 2-bromoethylamine hydrobromide (384mg, 1.872mmol). Acetic anhydride (400muL) was added and the reaction sealed and heated to 120C for 30min. The reaction was cooled to ambient temperature and diluted with H2O (2mL). The crude solid was filtered and washed with H2O (2¡Á5mL) and purified by eluting through a plug (SiO2; CH2Cl2) to obtain the product as a mixed halo compound, which was used without further purification. Yield=417mg. Compound 5b was obtained as an approximately 1:1 mixture of the dichloro- and bromochloro- diazaphthalimide as a result of the ammonium counter anion becoming partially exchanged into the pyrazine ring. Attempts to prevent this halide exchange using excess NH4Cl yielded significant amounts of inseparable 5a as a side-product. Nevertheless, 5b was reacted on as the mixed halide species with no significant impact on the subsequent synthesis of 1b (vide supra). (0024) 1H NMR (500MHz, CDCl3): delta 4.24 (t, 3JHH=6.4, 2H, CH2), 4.23 (t, 3JHH=6.4, 2H, CH2), 3.67 (t, 3JHH=6.4, 2H, CH2), 3.66 (t, 3JHH=6.4, 2H, CH2). 13C{1H} NMR (126MHz, CDCl3): delta 162.0, 161.9, 161.8, 161.8, 156.4, 154.1, 150.3, 147.4, 143.9, 143.7, 143.7, 143.4, 40.2, 40.2, 27.7, 27.7. HR ESI-MS positive ion: 379.9013m/z [C8H4BrCl2N3O2+Na+MeOH]+ (calc. 379.8995), 423.8489m/z [C8H4Br2ClN3O2+Na+MeOH]+ (calc. 423.8492). Anal. Calcd for C8H4Br1.5Cl1.5N3O2 (347.17gmol-1): C, 27.68; H, 1.16; N, 12.10. Found: C, 28.34; H, 0.92; N, 11.26; error <0.9%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 144692-85-3.
Reference:
Article; Knighton, Richard C.; Chaplin, Adrian B.; Tetrahedron; vol. 73; 31; (2017); p. 4591 – 4596;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem