Adding a certain compound to certain chemical reactions, such as: 33332-28-4, name is 2-Amino-6-chloropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33332-28-4, COA of Formula: C4H4ClN3
N-bromosuccinimide(NBS) (27.5 g, 155 mmol) was slowly added, was warmed up to room temperatureovernight (18 hours) and the mixture was stirred. Water was added thereto andthe product was extracted with ethyl acetate (¡Á 3). The organic layer waswashed with water (¡Á 1) and saturated brine (¡Á 1), and dried over anhydroussodium sulfate. After filtration, the filtrate was concentrated under reducedpressure, and the residue was purified by silica gel flash columnchromatography (n- hexane / ethyl acetate = 3/1),2-amino-3,5-dibromo-6-chloropyrazine (4) (16.8 g , 58.5 mmol, 94.7percent) as ayellow solid
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-6-chloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JNC CORPORATION; TOKYO MEDICAL AND DENTAL UNIVERSITY; INOUYE, SATOSHI; SAHARA, YUIKO; YOSHIDA, SUGURU; HOSOYA, TAKAMITSU; (47 pag.)JP5837973; (2015); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem