Reference of 153800-11-4, A common heterocyclic compound, 153800-11-4, name is 2-Ethynylpyrazine, molecular formula is C6H4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 197(100mg, 0.3 i9mmol)) and 10(36.6mg, 0.35 Immol) in 2OmL of Et3N was added Pd(PPh3)2C12 (11.21mg, 0.Ol6mmoi)and Cul (608mg, 0.O32mmol)). The mixture was protected under N2 atmosphere, then was heated at 70C for 4 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep4IPLC to give the target productCompound 80(25mg, yield: 27.1 %).LCMS: m/z 290 (,ff:[)-F;?H NMR (400 MTIz, CDCl) 8 78 (hi 111), 8 62.-8 55 (mn 21fl 8 21 (S 11-fl 7 9? s il-fl 7.83 (s. 1H), 7.76-7.73 (m, 1H), 7.357.32 (m, 1H).
The synthetic route of 153800-11-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem