Application of 78342-42-4, The chemical industry reduces the impact on the environment during synthesis 78342-42-4, name is (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine, I believe this compound will play a more active role in future production and life.
A solution of nBuLi (6.78 mL, 10.86 mmol, 1.6 M) in hexanes was added dropwise to a solution of (S)-2-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine (2.0 g, 10.86 mmol) in 20 mL of THF at -78 ¡ãC. After stirring for 30 mm at -78 ¡ãC, a solution of 5-bromo-2-(bromomethyl)-1,3- difluorobenzene (3.10 g, 10.86 mmol) in 10 mL of THF was added and the reaction mixture was stirred at -78 ¡ãC for 3 h. Then 20 mL of saturated NH4C1 solution was added. After the reaction mixture was warmed to room temperature, 150 mL of water was added and the mixture was extracted with EtOAc three times. The combined organic layers were dried over MgSO4, filtered, and concentrated. Purification by silica gel chromatography (eluting with 0 to 15percent EtOAc/Hexanes) afforded (2R, 5 S)-2-(4-bromo-2, 6-difluorobenzyl)-5 -i sopropyl-3 ,6-dimethoxy- 2,5-dihydropyrazine. ?H NIVIR (CDC13, 300 MHz) (ppm): 7.03 (d, J = 7.04 Hz, 2H), 4.14-4.32 (m, 1H), 3.71 (s, 3H), 3.58 (s, 3H), 3.13-3.33 (m, 1H), 2.79-2.93 (m, 1H), 2.13-2.33 (m, 1H), 1.00 (d, J 7.04 Hz, 3H), 0.64 (d, J 7.04 Hz, 3H). MS: (ESI, m/z): 389, 391 [M+H]t
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (S)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FORMA THERAPEUTICS, INC.; ZABLOCKI, Mary-Margaret; GUERIN, David J.; NG, Pui Yee; WANG, Zhongguo; SHELEKHIN, Tatiana; CARAVELLA, Justin; LI, Hongbin; IOANNIDIS, Stephanos; (518 pag.)WO2019/32863; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem