Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27825-20-3, name is Methyl 3-Hydroxy-2-pyrazinecarboxylate, A new synthetic method of this compound is introduced below., name: Methyl 3-Hydroxy-2-pyrazinecarboxylate
458 g (3 mol, 1 eq) of methyl 3-hydroxy-2-pyrazinecarboxylate and 532 g (3 mol, 1 eq) Bromosuccinimide were successively added to 5 L of acetonitrile,The mixture was stirred at 25 C for 12 hours,After TLC detection reaction was complete,The reaction was stopped,filter,Filter cake vacuum drying at room temperature,To give 554 g of methyl 6-bromo-3-hydroxy-2-pyrazinecarboxylate (including tautomer 6-bromo-3-oxo-3,4-dihydro-2-pyrazinecarboxylic acid Methyl ester),The yield was 85%. 6-Bromo-3-hydroxy-2-pyrazinecarboxylic acid methyl ester
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Qingdao Hangdao District Chinese Medicine Hospital; Lu, Yanmin; (5 pag.)CN105732524; (2016); A;,
Pyrazine – Wikipedia,
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