Related Products of 113305-94-5,Some common heterocyclic compound, 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, molecular formula is C5H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 2-amino-5-cyanopyrazine (500.0 mg, 4.162 mmol) in 1,4- dioxane (8.3 ML) was treated with 4- (dimethylamino) pyridine (305.1 mg, 2.497 mmol), N, N, N’, N’-TETRAMETHYLETHYLENEDIAMINE (241.8 mg, 2.081 mmol), and di-tert-butyl dicarbonate (2.9 mL, 12.49 mmol). The reaction stirred at 25C for 20 h and then was concentrated in vacuo. Biotage chromatography (FLASH 40M, Silica, 10% ethyl acetate/hexanes) afforded 5- [ [BIS [ (L, 1-dimethylethoxy) carbonyl] ] amino]-2- pyrazinecarbonitrile as a white solid: mp 67-68C ; (ES) +-HRMS m/e calcd for CISH2ON404 (M+Na) + 343. 1377, found 343.1379.
The synthetic route of 113305-94-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem