Some common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H6N2
Step C??Synthesis of mt 7-3 10347] To a solution of 2-methylpyrazine (272 mg, 2.9 mmol) and HMPA (520 mg, 2.9 mmol) in THF (2.5 mE) was added EDA (1.6 mE, 3 mmol) at ?78¡ã C. dropwise. The mixture was allowed to stir at ?78¡ã C. for 30 minutes before a solution of mt 7-2 (600 mg, 2.45 mmol) in 2 mE of THF was added. The mixture was allowed to warm to room temperature for 3 hours before it was quenched with 10 mE of saturated NH4C1 solution. The resulting mixture was extracted with EtOAc (3×10 mE) and the combined organic washings were dried over sodium sulfate, filtered and in vacuo. The resulting residue was purified using column chromatography (25percent EtOAc/petroleum ether) to provide mt 7-3 (100 mg, 12percent). MS (ESI): mlz (M+H) 339.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 109-08-0, its application will become more common.
Reference:
Patent; Coburn, Craig A.; Maletic, Milana; Soll, Richard; Li, Chunsing; Luo, Yunfu; Qi, Zhiqi; US2014/5103; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem