Synthetic Route of 98-97-5, The chemical industry reduces the impact on the environment during synthesis 98-97-5, name is Pyrazine-2-carboxylic acid, I believe this compound will play a more active role in future production and life.
Step 1 (esterification of pyrazine-2-carboxylic acid to yield methyl-pyrazine-2-carboxylate): To a 1L single-neck round-bottomed flask fitted with condenser and drying tube filled with silica gel was charged methanol (400 mL) with agitation at room temperature. Pyrazine-2-carboxylic acid (50.00 g, 402.90 mmol) was charged to the flask in one portion and the resulting slurry was vigorously stirred. Conc. sulfuric acid (0.25 mL) was charged to the slurry. The slurry was heated to reflux temperature and stirred at this temperature for 2 days. The resulting pale yellow solution was allowed to cool to room temperature. This process takes 90 minutes. Solid sodium bicarbonate (4.00 g, 47.62 mmol) was added to the solution in one portion and the slurry was stirred vigorously for 30 minutes. The suspension was filtered and the filtrate was transferred to a 2L single-neck round-bottomed flask and concentrated to about half volume in vacuo a 35 C. Toluene (1200 mL) was added to the methanol solution and a Dean-Stark trap fitted with drying tube was attached. The solution was heated at atmospheric pressure (external oil bath a120 C.) and the first 300 mL solvent fraction was run off and discarded. The Dean-Stark trap was removed and the reaction solution was concentrated in vacuo a45 C. to a volume of 300 mL. The organic phase containing the desired methyl-pyrazine-2-carboxylate was filtered to remove solid particulates and used directly in the next step as a solution in toluene (a small analytical sample was removed and concentrated in vacuo a 35 C. to yield a pale brown solid, m.p. 60-61 C., structure confirmed by 1H NMR and 13C NMR).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Patrick Prendergast; US2004/53989; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem