Reference of 912773-24-1,Some common heterocyclic compound, 912773-24-1, name is 6-Bromoimidazo[1,2-a]pyrazine, molecular formula is C6H4BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 20 mL Biotage microwave vial loaded with 6-bromoimidazo[1,2-a]pyrazine (120 mg, 0.606 mmol), pyridin-4-ylboronic acid (82 mg, 0.667 mmol), Pd(PPh3)4 (63 mg, 0.055 mmol), and NaHCO3 (204 mg, 2.424 mmol), was capped, purged with argon, then injected with degassed dioxane: H2O (3.73 mL: 0.93 mL, 4:1 v/v), and heated to 140 for 40 min in a Biotage Microwave Reactor. The reaction was cooled, diluted with DCM, filtered through celite, concentrated, dryloaded onto silica gel and purified on a 12 g silica gel column (DCM/MeOH, 0-8%), affording 6-(pyridin-4-yl)imidazo[1,2-a]pyrazine 66 as a white solid (85 mg, 0.433 mmol, 72% yield, 8% MeOH). 1H NMR (DMSO) delta: 9.45 (d, J=1.5 Hz, 1H), 9.21 (dd, J=1.5, 0.7 Hz, 1H), 8.70 (d, J=6.2 Hz, 2H), 8.18 (s, 1H), 8.01 (d, J=6.2 Hz, 2H), 7.91 (d, J=1.1 Hz, 1H). 13C NMR (DMSO) delta: 150.78, 144.04, 143.05, 140.21, 136.70, 135.33, 120.33, 119.05, 116.10.
The synthetic route of 912773-24-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Arizona Board of Regents on Behalf of the University of Arizona; Hulme, Christopher; Foley, Christopher; (166 pag.)US2020/39989; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem