117103-53-4, name is 2-Bromo-5-nitropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C4H2BrN3O2
Example 13 2 (R)- (3-CHLORO-4-METHANESULFONYL-PHENYL)-3-CYCLOPENTYL-N- (5- METHANESULFONYLAMINO-PYRAZIN-2-YL)-PROPIONAMIDE [000164] A solution of molten acetamide (1.58 g, 26.7 mmol) heated to 90C was treated with a mixture of 2-bromo-5-nitropyrazine (1.34 g, 6.58 MMOL), METHANESULFONAMIDE (1.88 g, 19.7 mmol), and potassium carbonate (2.30 g, 16.6 mmol). The resulting mixture was quickly brought to 145C. The resulting solution was stirred at 145C for 30 min. At this time, the reaction was cooled to 25C and then was treated with water (4 mL). This solution was cooled to 0C and then was treated with a IN aqueous hydrochloric acid solution until the pH of the solution was adjusted to pH=8. This solution was treated with charcoal and was filtered through a pad of celite (90/10 methylene chloride/methanol wash). The filtrate was partitioned, and the aqueous layer was extracted with a solution of 90/10 methylene CHLORIDE/METHANOL. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60,230-400 mesh, ethyl acetate) afforded N- (5-nitro- PYRAZIN-2-YL)-METHANESULFONAMIDE (583.9 mg, 40.6%) as a yellow solid: mp 204-207C ; EI-HRMS m/e calcd for C5H6N404S (M+H) + 219. 0183, found 219.0185.
The synthetic route of 117103-53-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/52869; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem