Application of 914452-71-4, A common heterocyclic compound, 914452-71-4, name is 2-Bromo-6-methylpyrazine, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred solution of 1 (100mg, 577.99mumol), 2 (168mg, 924.79mumol) in DMF:water (5mL, 1:1), it was added Na2CO3 (141 mg, 1.33 mmol) and 1 mg of PdNP at room temperature. The resulting reaction mixture was heated at 100 C for 15 min, after completion of reaction reaction mass was cooled to room temperature, diluted with H2O (10 mL) and extracted with EtOAc (3×15 mL). The combined organic layer was washed with brine solution, dried over Na2SO4, filtered and concentrated under reduced pressure to afford crude compound, which was triturated with pet ether to delivered 3 (120 mg, 90%) as off-white solid. 1H NMR (500 MHz, CDCl3) delta: 8.79 (d, J = 5.0 Hz, 1H), 8.34 (d, J = 5.0 Hz, 1H), 7.70 – 7.51 (m, 1H), 7.04 – 6.92 (m, 1H), 4.09 – 3.89 (m, 2H), 2.66 – 2.59 (m, 1H); 13C NMR (126 MHz, CDCl3) delta 153.01, 151.40, 150.56, 149.51, 141.92, 138.57, 129.50, 119.66, 111.23, 109.83, 56.02, 56.01, 21.76; LC-MS (ESI): 231.16 (M+H).
The synthetic route of 914452-71-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bendre, Ameya D.; Kodam, Kisan M.; Patil, Viraj P.; Terdale, Santosh S.; Waghmode, Suresh B.; Journal of Organometallic Chemistry; vol. 909; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem