In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-08-0, name is 2-Methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 2-Methylpyrazine
Butyllithium (1.6 M in hexane solution, 10 ml, 16 mmol) was added dropwise to a solution of diisopropylamine (2.25 ml, 16 mmol) in anhydrous THF (50 ml) at -20¡ãC under a nitrogen atmosphere. The mixture was stirred at -20¡ãC for 30 minutes and after cooling at -70¡ãC a solution of 2-methyl-pyrazine (1.47 ml, 16 mmol) in THF (10 ml) was added dropwise. After 15 minutes, a solution of 3-bromo-propionic acid ethyl ester (2.54 ml, 19.2 mmol) in THF (10 ml) was added and the mixture maintained at -70¡ãC for 2 hours and then stirred at room temperature overnight. The reaction was then quenched with a saturated solution of NH4Cl and extracted with ethyl acetate, the organic phase was dried (Na2SO4) and evaporated. The residue was purified by flash chromatography (hexane/ ethyl acetate from 9/1 to 1/1 respectively) to give the title compound (1 g, 33percent yield). UPLC/MS: 195.1 (MH+).
The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Neurotune AG; EP2098526; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem