Synthetic Route of 2423-65-6, The chemical industry reduces the impact on the environment during synthesis 2423-65-6, name is Pyrazine 1-oxide, I believe this compound will play a more active role in future production and life.
1) Take 0.25mmol of pyrazine nitrogen oxide,diphenyl disulfide 0.45mmol,Cu(AcO)2 0.125 mmol and potassium hydroxide 0.5 mmol,add 1 mL of toluene to make a mixture,the mixture was placed in a 5 ml Schlenk tube,heated in an oil bath at 130C,after 48 hours of reaction,cool to room temperature to obtain the reaction solution;2) Concentrate the reaction solution to obtain a concentrate, and use a mixed solvent of ethyl acetate and petroleum ether in a volume ratio of 1:3 as a developing agent, and use silica gel as an adsorbent to perform thin layer chromatography to obtain 16 mg of the target product. The target product yield of this example is 32%, and the target product is subjected to nuclear magnetic characterization.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine 1-oxide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Henan Agricultural University; Wu Zhiyong; Zhao Mingqin; Lai Miao; (13 pag.)CN108017581; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem