Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 77112-52-8, name is Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C9H9N3O2
[0079] Method A-Step b: Preparation of 7-tert-butyl-2-ethyl-5,6-dihydroimidazo[l,2- a]pyrazine-2 -dicarboxylate [0080] To a solution of ethyl imidazo[l,2-a]pyrazine-2-carboxylate (1 g, 5.2 mmol) in 500 mL ethyl alcohol was added Boc20 (3.0 g, 18 mmol) and 200 mg 10% Pd-C (50% wet) under hydrogen atmosphere, then the mixture was stirred at room temperature for 24 hours. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography and eluted with (CH2Cl2:MeOH = 50:1). The title compound was obtained as a yellow oil (0.973 g, 63%). *H NMR (400 MHz, CDCI3) delta 7.51(s, 1H), 4.68 (s, 2H), 4.30 (q, 7 = 7.1 Hz, 2H), 4.00 (t, 7 = 5.2 Hz, 2H), 3.82 (t, 7 = 5.2 Hz, 2H), 1.43 (s, 9H), 1.21 (t, 7 = 7.1 Hz, 3H).
The synthetic route of 77112-52-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem