Related Products of 939412-86-9, A common heterocyclic compound, 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, molecular formula is C5H7Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 2-aminomethyl-3-chloropyrazine hydrochloride (content 80%; 4.44 mmol, 1 g) and N,N- diisopropylethylamine (17.77 mmol, 3.10 ml) in dichloromethane (20 ml) under N2 at 0C was added N- methylpiperazin-4-carbamoyl chloride hydrochloride (4.89 mmol, 0.973 g). After stirring at room temperature for 18 hours water was added and the mixture extracted three times with ethyl acetate. The combined organic layers were washed with brine, dried (sodium sulfate) and concentrated in vacuo. Purification by column chromatography (silica gel; dichloromethane with gradient 0 to 10% methanol) gave N-((3-chloropyrazin-2-yl)methyl)-4-methylpiperazine-1 -carboxamide (513 mg).
The synthetic route of 939412-86-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; N.V. ORGANON; MAN de,, Adrianus Petrus Antonius; REWINKEL,, Johannes Bernardus Maria; JANS,, Christiaan Gerardus Johannes Maria; RAAIJMAKERS,, Hans Cornelis Andreas; WIJKMANS,, Jacobus Cornelis Henricus Maria; WO2011/95556; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem