Electric Literature of 4744-50-7, These common heterocyclic compound, 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
a 3-(m-methylbenzoyl)-pyrazine-2-carboxylic acid The Grignard reagent from 8.5 g (50 mmol) 3-bromotoluene and 1.2 g magnesium in 50 ml ether was added dropwise at 0-10 C. to a solution of 7.5 g (50 mmol) pyrazine-2,3-dicarboxylic acid anhydride in 100 ml THF and after completed addition, the solution that formed was stirred for 4 hours at room temperature. 500 ml cold, saturated NH4 Cl solution was then added, it was extracted with ethyl acetate and the organic phase was dried, concentrated by evaporation and purified as in example 1a and 2a. Yield 4 g (32% of theoretical yield).
Statistics shows that 2,3-Pyrazinecarboxylic anhydride is playing an increasingly important role. we look forward to future research findings about 4744-50-7.
Reference:
Patent; Boehringer Mannheim GmbH; US5512564; (1996); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem