The origin of a common compound about 2-Amino-3,5-dibromopyrazine

The synthetic route of 24241-18-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24241-18-7, name is 2-Amino-3,5-dibromopyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C4H3Br2N3

Step 1: 5-Bromo-3-trimethylsilanylethynyl-pyrazin-2-ylamine To a 150 mL round-bottomed flask was added 3,5-dibromopyrazin-2-amine (3 g, 11.86mmol) and triethylamine (16.53 ml, 119 mmol) in THF (60 ml) to give a yellow suspension.To the stirring solution was added bis(triphenylphosphine)palladium(ll) chloride (833mg, 1.l86mmol) and copper(l) iodide (452mg, 2.373mmo1). Whilst maintaining the temperature below 10C, ethynyltrimethylsilane (1.844m1, 13.OSmmol) was added slowly and the reaction stirred at below 10C for 30mins before warming to room temperature and stirring for afurther 30mins.The reaction was concentrated under reduced pressure. After dilution with ethyl acetate the organics were washed with brine, the organic layer separated, dried over Mg504, filtered and the solvent removed under reduced pressure. The residue was loaded onto silica and purified by flash column chromatography, elution with iso hexane:ethyl acetate (0-30%) onan 80g silica column. The required fractions were combined and the solvent removed under reduced pressure to yield the product as a light brown solid (2.5g).

The synthetic route of 24241-18-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; BELLENIE, Benjamin Richard; BLOOMFIELD, Graham Charles; BRUCE, Ian; CULSHAW, Andrew James; HALL, Edward Charles; HOLLINGWORTH, Gregory; NEEF, James; SPENDIFF, Matthew; WATSON, Simon James; (395 pag.)WO2015/162459; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem