912773-21-8, name is 2-Bromo-5-chloropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H2BrClN2
A mixture of 2-bromo-5-chloro-pyrazine (800 mg, 4.14 mmol), 3-fluoro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2-[l- (trifluoromethyl)cyclobutoxy]pyridine (1642.99 mg, 4.55 mmol), CS2CO3(4042.64 mg,12.41 mmol), Pd(dppf)Cl2(60.52 mg, 0.08 mmol) in l,4-dioxane (12 mL) and H2O (4 mL) was stirred at 50 C for 8 hours. After cooling to room temperature, the reaction mixture was concentrated to remove solvent, diluted with water (20 mL), and extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (40 mL), dried over Na2S04and concentrated to give a crude product. The crude product was purified by flash chromatography on silica gel (EtOAc in PE = 0% to 10%) to give the product as a solid, which was confirmed by LCMS Rt= 1.01 min in 1.5 min chromatography, MS ESI calcd. for C14H11CIF4N3O [M+H]+348.1, found 347.9.
The synthetic route of 912773-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; GRIFFIN, Andrew, Mark; MARRON, Brian, Edward; MARTINEZ BOTELLA, Gabriel; REDDY, Kiran; WITTMANN, Marion; (0 pag.)WO2019/232209; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem