Synthetic Route of 91476-80-1, These common heterocyclic compound, 91476-80-1, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
C-1 a (50 mg; 0.16 mmol) is dissolved in dioxane. 5,6,7,8-tetrahydro-imidazo[1 ,2- a]pyrazine E-1a (19 mg; 0.16 mmol), sodium ie f-butoxide (40 mg; 0.42 mmol) and chloro(2-dicyclohexylphosphino-2′,4′,6′-tri-isopropyl-1 ,1 ‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-i-butyl ether adduct (9 mg; 0.01 mmol) are added and the reaction mixture is stirred at 75 C for 2 h. The solvents are evaporated under reduced pressure and the crude material is purified using reversed phase chromatography (method: prep. HPLC1 ) to afford I-029. Yield: 48 % (27 mg; 0.08 mmol) HPLC-MS: (M+H)+ = 362; tRet = 0.96 min; method LCMSBAS1
The synthetic route of 91476-80-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; ARNHOF, Heribert; CAROTTA, Sebastian; HOFMANN, Marco; KERENYI, Marc; SCHARN, Dirk; (118 pag.)WO2019/68613; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem