In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 243472-70-0 as follows. Product Details of 243472-70-0
Add 3-methyl-2-bromo-quinoxaline (622 mg, 2.00 mmol) to cis-5-(isopropylamine) under nitrogen.a solution of methyl-)tetrahydrofuran-2-yl)methanol (1.04 g, 6.00 mmol) in N-methylpyrrolidone (20 mL)After refluxing at 170 C for 15 h, the reaction was monitored by LC-MS, the starting material was completely reacted, and the reaction was cooled and ice water was added to the reaction solution.The ethyl acetate (50 mL*3) was extracted, and the organic mixed phase was washed with water (50 mL) and saturated brine (50 mL*2).Filtration, decompression to solvent, purification by chromatography on silica gel column, and collected under reduced pressure.Drying in vacuo gave 673 mg of Compound VIII as a white solid.
According to the analysis of related databases, 243472-70-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chengdu Yuandong Bio-pharmaceutical Co., Ltd.; Zeng Yanqun; Yan Shengyong; Zhang Tao; Wang Ying; (17 pag.)CN108623541; (2018); A;,
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