Reference of 22047-25-2, A common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A stirred solution of 1-(pyrazin-2-yl)ethanone (1.24 g, 0.01 mol) in methanol (20 ml) was added dropwise to a solution of 4-chloro-6-hydrazinylpyrimidine (1.44 g,0.01 mol) in methanol (30 ml) plus three drops of glacial acetic acid. The mixture was refluxed for 4 h and then cooled to room temperature. The precipitated solid was filtered off and washed with cold methanol to obtain a white solid. Yield: 86.3 %. 1H NMR (400 MHz, DMSO) d ppm: 11.16 (s, 1H), 8.62-8.53 (m, 5H), 9.46 (s, 1H), 7.48(s, 1H), 2.40 (s, 3H). (Fig. S1). 13C NMR (100 MHz,DMSO) dppm: 162.94, 159.80, 158.21, 150.26, 148.14,143.83, 143.13, 142.63, 102.99, 11.91. (Fig. S2). ESI-MS (DMF, positive ion mode): m/z = 249.07([M + H]+), C10H9ClN6 theoretical mass: 248. (Fig. S3). IR/cm-1(KBr):1565 (s), 1369 (m), 3150 (m), 3438 (m).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Hasi, Qi-Meige; Fan, Yan; Feng, Xiao-Xia; Yao, Xiao-Qiang; Liu, Jia-Cheng; Transition Metal Chemistry; vol. 41; 6; (2016); p. 685 – 692;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem