Electric Literature of 16298-03-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16298-03-6 as follows.
Step 1: Synthesis of 3-amino-6-iodo-pyrazine-2-carboxylic acid methyl ester.[0295] Methyl 3-amino-2-pyrazinecarboxylate (10 g, 65.3 mmol) and N-iodosuccinimide(24 g, 106.7 mmol) were dissolved in anhydrous DMF (150 mL) and the mixture wasstirred at 70 ¡ãC for 15 hours under a nitrogen atmosphere. The mixture was then cooled toroom temperature and a saturated aqueous solution of sodium thiosulfate (400 mL) wasadded. The suspension was sonicated for 15 minutes, concentrated under vacuum anddispersed in water. The crude product was filtered off and washed with cold ethanol. Theresidue was crystallized from ethanol, using decolorizing charcoal to afford 3-amino-6-iodo-pyrazine-2-carboxylic acid methyl ester (11.2 g, 61 percent yield) as orange needles. 1H-NMR (d6-DMSO) 8.57 [1H] s, 7.59 [2H] s,br, 3.93 [3H] s. MS: m/z 280 [MH+].
According to the analysis of related databases, 16298-03-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SGX PHARMACEUTICALS, INC.; WO2006/15124; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem