Related Products of 143591-61-1, The chemical industry reduces the impact on the environment during synthesis 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, I believe this compound will play a more active role in future production and life.
Method B 3-Bromo-?/-(3′-(trifluoromethyl)phenyl)imidazori,2-alpyrazin-8-amine [00247] Sodium hydride (84 mg, 2.10 mmol – 60% in mineral oil) was dissolved in DMSO (2mL). 3-(Trifluoromethyl)aniline (340 mg, 0.263 mL, 2.11 mmol) was then added and the resulting mixture was stirred at room temperature under a nitrogen gas atmosphere for 10 minutes. A solution of 3-bromo-8-bromo/chloroimidazo[l,2-a]pyrazine (245 mg, 1.05 mmol) in DMSO (2 mL) was then added and stirring at room temperature under a nitrogen gas atmosphere continued for another 2 hours. The reaction was quenched by the addition of saturated ammonium chloride solution (aq.) followed by extraction into EtOAc. The organic extracts were washed with brine, dried and concentrated in vacuo. Purification by flash column chromatography (gradient 7:1 to 6:1 40-60 petrol :EtO Ac) followed by trituration with 40-60 petrol gave the title compound (98 mg, 26%) as a white powder. 1H NMR (d6- DMSO): 10.12 (IH, s), 8.58 (IH, br s), 8.32 (IH, d, J 8.5 Hz), 7.88 (IH, d, J4.6), 7.85 (IH, s), 7.63 (IH, d, J4.7), 7.56 (IH, t, J7.9), 7.35 (IH, d, J7.8).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; PRICE, Paul Damien; MIDDLETON, Penny; WO2010/69684; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem