Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 17231-51-5, name is 3-Amino-6-bromopyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 17231-51-5
REFERENTIAL EXAMPLE II-9 In 10 mL of tetrahydrofuran was dissolved 0.50 g of 3-amino-6-bromo-2-pyrazinecarbonitrile. After adding 0.15 g of 60% sodium hydride, the mixture was stirred at room temperature for 15 minutes. Then, 0.7 mL of di-t-butyl dicarbonate and 0.10 g of 60% sodium hydride were successively added, and the mixture thus formed was stirred at room temperature for one hour. The reaction mixture was added to a liquid mixture consisting of 30 mL of ethyl acetate and 60 mL of water, pH was adjusted to 5 with 2 mol/L hydrochloric acid, and the organic layer was separated. The organic layer was washed successively with water and saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue thus obtained was purified by silica gel column chromatography [eluent: n-hexane:ethyl acetate=5:1] to obtain 0.30 g of t-butyl 5-bromo-3-cyano-2-pyrazinylcarbamate as a white-colored solid product. IR(KBr) cm-1: 2239, 1708 1H-NMR (CDCl3+DMSO-d6) delta: 1.57(9H,s), 7.41(1H,brs), 8.62(1 H,s)
The synthetic route of 17231-51-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
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