Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 144692-85-3, name is 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione, A new synthetic method of this compound is introduced below., Application In Synthesis of 2,3-Dichlorofuro[3,4-b]pyrazine-5,7-dione
Under air, a test tube was charged with 2,3-dichlorodiazaphthalic anhydride (410mg, 1.872mmol) and 2-chloroethylamine hydrochloride (223mg, 1.919mmol). Acetic anhydride (400muL) was added and the reaction sealed and heated to 120C for 30min. The reaction was cooled to ambient temperature and diluted with H2O (2mL). The crude solid was filtered and washed with H2O (2¡Á5mL) and then purified by eluting through a plug (SiO2; CH2Cl2) to afford analytically pure 5a as a white solid. Yield=391mg (75%). (0022) 1H NMR (500MHz, CDCl3): delta 4.18 (t, 3JHH=6.1, 2H, CH2), 3.83 (t, 3JHH=6.1, 2H, CH2). 13C{1H} NMR (126MHz, CDCl3): delta 161.9, 154.1, 143.4, 40.5, 40.4. HR ESI-MS positive ion: 333.9521m/z [M+Na+MeOH]+ (calc. 333.9523). Anal. Calcd for C8H4Cl3N3O2 (280.49gmol-1): C, 34.26; H, 1.44; N, 14.98. Found: C, 34.33; H, 1.38; N, 14.96.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Knighton, Richard C.; Chaplin, Adrian B.; Tetrahedron; vol. 73; 31; (2017); p. 4591 – 4596;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem