Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.290-37-9, Name is Pyrazine, SMILES is C1=NC=CN=C1, belongs to Pyrazines compound. In a document, author is Kergreis, Angelique, introduce the new discover, Safety of Pyrazine.
Influence of Ligand and Nuclearity on the Cytotoxicity of Cyclometallated C boolean AND N boolean AND C Platinum(II) Complexes
A series of cyclometallated mono- and di-nuclear platinum(II) complexes and the parent organic ligand, 2,6-diphenylpyridine1((HCNCH)-N-boolean AND-C-boolean AND), have been synthesized and characterized. This library of compounds includes [((CNC)-N-boolean AND-C-boolean AND)Pt-II(L)] (L=dimethylsulfoxide (DMSO)2and triphenylphosphine (PPh3)3) and [(((CNC)-N-boolean AND-C-boolean AND)Pt-II)(2)(L’)] (whereL’=N-heterocycles (pyrazine (pyr)4, 4,4′-bipyridine (4,4′-bipy)5or diphosphine (1,4-bis(diphenylphosphino)butane (dppb)6). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes (4-6), when compared to the mononucleated species (2and3). Complex 6is the most promising candidate, displaying very high selectivity towards cancerous cells, with selectivity index (SI) values >29.5 (A2780) and >11.2 (A2780cisR), and outperforming cisplatin by >4-fold and >18-fold, respectively.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 290-37-9 is helpful to your research. Safety of Pyrazine.