Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2847-30-5, Name is 2-Methoxy-3-methylpyrazine, SMILES is COC1=C(C)N=CC=N1, belongs to Pyrazines compound. In a document, author is Dagar, Anuradha, introduce the new discover, Recommanded Product: 2847-30-5.
A domino annulation approach to 3,4-diacylpyrrolo[1,2-a]pyrazines: decoration of pyrazine units
A new one-pot, sequential three-component access to 3,4-diacylpyrrolo[1,2-a]pyrazine was achieved from the reaction of an alpha-haloketone, azide, and N-substituted pyrrole-2-carboxaldehyde under mild reaction conditions, through which a polysubstitution pattern on the pyrazine moiety of the scaffold was realized. The formation of multiple bonds (one C-C and two C-N) was enabled by this domino process involving the in situ generation of alpha-iminoketones, intermolecular Mannich reaction, intramolecular imine formation, and aromatization. Construction of the relevant 3,4-diacylpyrazino[1,2-a]indole and further expansion of this chemical space via synthetic elaboration of the resulting products were demonstrated as well. Preliminary biological screening of the synthesized derivatives against oral adenosquamous carcinoma cells (CAL-27) and triple negative human breast cancer cells (MDA-MB-231) led us to identify a potent hit compound (7o) having similar to 3 times stronger in vitro anticancer activity than that of the anticancer agent, capecitabine.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2847-30-5 is helpful to your research. Recommanded Product: 2847-30-5.