In an article, author is Karaaslan, Cigdem, once mentioned the application of 22047-25-2, COA of Formula: C6H6N2O, Name is Acetylpyrazine, molecular formula is C6H6N2O, molecular weight is 122.1246, MDL number is MFCD00006134, category is Pyrazines. Now introduce a scientific discovery about this category.
Regioselective N-alkylation of some imidazole-containing heterocycles and their in vitro anticancer evaluation
Imidazole-containing heterocycles: Imidazopyridines, imidazopyrimidines and imidazopyra-zines can exist more tautomeric forms than benzimidazoles. Their regioselectivities were determined for N-alkylations with 4-fluorobenzyl bromide under basic conditions (K2CO3) in DMF. We observed that, regioisomers were mainly formed as a mixture in this reaction and N-benzylation occurs at a higher ratio on six membered heterocycles. Their structural assignments were made with the use of two-dimensional H-1-H-1 NOE (nuclear overhauser effect spectroscopy, NOESY). Complementary structural informationwas provided by 2D-HMBC spectra of the compounds. Synthesized compounds were tested for in vitro cytotoxic activities against Human colon cancer cell line (HCT-116) and leukemia cell lines (K562 and HL-60) by MTT test. Among them, imidazopyridine analogue 10, bearing bromine atom at the C-6 position of the pyridine moiety, gave the lowest IC50 value with 6-7 mu g/mL against all three cancer cell lines. (C) 2020 Elsevier B.V. All rights reserved.
If you are interested in 22047-25-2, you can contact me at any time and look forward to more communication. COA of Formula: C6H6N2O.