In an article, author is Lehnherr, Dan, once mentioned the application of 123-32-0, Name is 2,5-Dimethylpyrazine, molecular formula is C6H8N2, molecular weight is 108.14, MDL number is MFCD00006147, category is Pyrazines. Now introduce a scientific discovery about this category, Application In Synthesis of 2,5-Dimethylpyrazine.
Electrochemical Synthesis of Hindered Primary and Secondary Amines via Proton-Coupled Electron Transfer
Accessing hindered amines, particularly primary amines alpha to a fully substituted carbon center, is synthetically challenging. We report an electrochemical method to access such hindered amines starting from benchtop-stable iminium salts and cyanoheteroarenes. A wide variety of substituted heterocycles (pyridine, pyrimidine, pyrazine, purine, azaindole) can be utilized in the cross-coupling reaction, including those substituted with a halide, trifluoromethyl, ester, amide, or ether group, a heterocycle, or an unprotected alcohol or alkyne. Mechanistic insight based on DFT data, as well as cyclic voltammetry and NMR spectroscopy, suggests that a proton-coupled electron-transfer mechanism is operational as part of a hetero-biradical cross-coupling of a-amino radicals and radicals derived from cyanoheteroarenes.
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