A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 290-37-9, Name is Pyrazine, molecular formula is C4H4N2. In an article, author is Tiwari, Mohit K.,once mentioned of 290-37-9, Computed Properties of C4H4N2.
[2,3-Bis-(2-pyridyl) pyrazine] as an Efficient Organocatalyst for the Direct C-(sp())2-H Arylation of Unactivated Arenes/Heteroarenes via C-H Bond Activation
Herein, we report the identification of 2,3-bis-(2-pyridyl) pyrazine as a new organocatalyst, which has been utilized for the direct cross-coupling reactions of an aryl halide with unactivated arenes/heteroarenesviaC((sp)())(2)-H bond activation. This transition metal-free C-H arylation of unactivated benzenes with aryl halides (Ar-X; X=I, Br, Cl) underwent smoothly with only 10 mol% of an organocatalyst and in the presence of 3 equivalent of potassiumtert-butoxide base which furnished a library of biaryls (3 a-u) in up to 98 % excellent yield under milder reaction conditions. The mechanistic pathway involves thein-situformation of aryl radical anion intermediate and progressedviaa single electron transfer (SET) mechanism. The wide substrate scope, high functional group forbearance, control/competition experiments, gram-scale synthesis and kinetic studies signify the prominence and useful nature of the protocol along with the steadiness of the novel organocatalyst.
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