Chemistry is an experimental science, Category: Pyrazines, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 290-37-9, Name is Pyrazine, molecular formula is C4H4N2, belongs to Pyrazines compound. In a document, author is Tong, Shuping.
Metal-organic framework with dual functional sites for CO2 catalytic fixation and treatment on COPD by down-regulating the tlr3 expression on the lung mucosal epithelial cells
A metal-organic framework based on Co(II), [Co-3(Ina)(2)(HIna)(2)(mu(2)-OH2)(L)](DMF)(4)}(n) (1, H4L = 5,5 ‘-(pyrazine-2,5-diyl)diisophthalic acid, HIna = isonicotinic acid), which has uncoordinated carboxylate groups and open N-donor sites, has been prepared by using the mixed-ligand approach under solvothermal conditions. Because of the synergetic role of dual functional sites of N-donor and free carboxylate groups, the resulting activated 1a demonstrates CO2 uptake capacity at room temperature and outstanding catalytic property in cycloaddition of epoxides and CO2 at mild conditions. Furthermore, the biological functional of the compound on the chronic obstructive pulmonary disease (COPD) treatment was evaluated. First, the relative expression of the tlr3 receptor on the lung mucosal epithelial cells was measured by RT-PCR. Then the inflammatory cytokines released by the lung mucosal epithelial cells were detected by ELISA detection kit after treatment.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 290-37-9, in my other articles. Category: Pyrazines.