Electric Literature of 19847-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 19847-12-2, Name is Pyrazinecarbonitrile, SMILES is N#CC1=NC=CN=C1, belongs to Pyrazines compound. In a article, author is Gawad, Jineetkumar, introduce new discover of the category.
Design, synthesis and biological evaluation of novel 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives as a potential DprE1 inhibitors
In a search of new potentially active antitubercular agents, here we have initiated with pharmacophore development, virtual screening and molecular docking studies to know flexible binding modes with target cavity of DprE1 enzyme. We have designed and synthesized 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives and evaluated for antitubercular activity with specific DprE1 inhibition. The various steps have been completed by performing conden-sation of 6-(trifluoromethyl)quinazoline-2-carboxylic acid, aromatic aldehydes, methanol, Hydrazine hydrate,-(trifluoromethyl)quinazoline-2-carbohydrazide, 6-(trifluoromethyl)-N’-methylenequinazoline-2-carbohydrazide to obtained 6-(trifluoromethyl)-N-(4-oxothiazolidin-3-yl)quinazoline-2-carboxamide derivatives (3a-r) in better yields. Synthesized derivatives were characterized for their spectral anal-ysis. These compounds have been screened for their in vitro antitubercular activity against Mycobacte-rium tuberculosis H 37 RV. The compounds 3a (MIC-1.27 m M); 3e (MIC-1.12 m M); 3p (MIC-1.18 m M); and 3r (MIC-0.96 m M); exhibited notable in vitro antitubercular activity compare to the reference standard, Isoniazid. These four compounds were screened for DprE1 enzyme assay. Among those 3e and 3r has shown strong DprE1 inhibition, these compounds were substituted with nitro and hydroxyl group. (c) 2020 Elsevier B.V. All rights reserved.
Electric Literature of 19847-12-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 19847-12-2.