Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 75907-74-3, name is (3,5,6-Trimethylpyrazin-2-yl)methanol, A new synthetic method of this compound is introduced below., name: (3,5,6-Trimethylpyrazin-2-yl)methanol
Step (1): in 50mL flask it contained QR01006-IN-01 (500mg, 3.29mmol), dichloromethane (10mL), and chloromethyl chloroformate (460mg, 3.6mmol), at -2 degrees and pyridine (0.32mL) was added dropwise to control the temperature not exceeding 3C. The reaction was warmed to room temperature overnight. TLC (petroleum ether/ethyl acetate=1/3) was done to monitor the completion of the reaction. The reaction was filtered and the filtrated was dried to give 1.1g yellow oil which was purified by preparative plate to give 620mg of yellow solid, yield: 77.3%. LCMS and HNMR spectra were used to confirm the structure.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Wuhan Langlai Science and Technology Development Co., Ltd.; Wuhan Qirui Pharmaceuticals Co., Ltd.; Ge, Jian; Ma, Jianyi; Xiang, Guangya; Wang, Wei; Wang, Chaodong; (44 pag.)CN105237527; (2016); A;,
Pyrazine – Wikipedia,
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