Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54608-52-5, name is 2-Hydrazinopyrazine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H6N4
General procedure: 2.5. General preparation of dregamine andtabernaemontanine derivatives 3-12Dregamine/tabernaemontanine (1/2) (1 equiv.) was dissolved in MeOH (3 mL) with the suitablehydrazine/hydroxylamine (3 equiv.) and a catalytic amount of acetic acid. Themixture was stirred under reflux for 2-24 h. The reaction mixture was extractedwith EtOAc (3 x 50 mL). The organic layers were combined and dried (Na2SO4).The solvent was removed under vacuum at 40 C and the obtained residue waspurified by column chromatography 2.5.6. Tabernaemontanine pyrazine-2-ylhydrazone(8) Obtained from reaction of the compound 2 with 2-hydrazinopyrazine(Sigma-Aldrich Chemie GmbH, Riedstrasse D-89555, Steinhelm, Germany; 3 equiv).The mixture was left under reflux for 24 h. The residue was purified by flashcolumn chromatography (silica gel CH2Cl2/MeOH 1:0 to93:7) to afford 10 mg (0.022 mol, yield 36 %) of an amorphous orange powder. IR(NaCl) vmax 3526,1730, 1656 cm-1.1H NMR (400 MHz, MeOD) delta 9.15 (1H, s, H-3?), 8.67 (1H, bs, H-6?),8.51 (1H, bs, H-5?), 8.16 (1H, d, J = 8.0 Hz, H-9), 8.03 (1H, bs, N-H), 7.93 (1H, d, J = 8.0Hz, H-12), 7.80 (1H, t, J = 7.8 Hz, H-11), 7.66 (1H, t, J = 7.6Hz, H-10), 4.55 (1H, td, J = 8.0, 3.0 Hz, H-5), 3.84 (2H, m, H-6), 3.60(3H, m, H-14, H-15), 3.50 (2H, m, H-16, H-21a), 3.21 (3H, s, -COOMe),3.11 (3H, s, N-Me), 2.33 (2H, m, H-19), 2.19 (1H, m, H-21b), 2.10 (1H, m,H-20), 1.62 (3H, t, J = 7.3 Hz, H-18) ppm; 13C NMR (101 MHz,MeOD) delta 173.2 (-COOMe), 155.5 (C-3), 153.9 (C-2?), 142.7 (C-6?), 141.8(C-5?), 138.0 (C-13), 134.3 (C-3?), 131.0 (C-8), 124.6 (C-11), 119.9 (C-10),119.7 (C-9), 115.2 (C-7), 111.7 (C-12), 59.3 (C-5), 50.9 (-COOMe), 46.8(C-21), 43.6 (N-Me), 43.0 (C-20), 42.9 (C-16), 34.0 (C-15), 32.2 (C-14), 26.5(C-19), 19.4 (C-6), 13.1 (C-18) ppm. HRMS-ESI-TOF m/z calcd C25H30N6O2[M+H] + 447.2430, found 447.2510.
According to the analysis of related databases, 54608-52-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Paterna, Angela; Borralho, Pedro M.; Gomes, Sofia E.; Mulhovo, Silva; Rodrigues, Cecilia M.P.; Ferreira, Maria-Jose U.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 17; (2015); p. 3556 – 3559;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem