4949-13-7, name is 2-Fluoropyrazine, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C4H3FN2
Example 65(4-cyclobutylpiperazin-1-yl)(7-(pyrazin-2-yl)-7-azaspiro[3.5]nonan-2-yl)methanone A mixture of Intermediate 7 (100 mg, 0.34 mmol), 2-fluoropyrazine (141 mg, 1.44 mmol), DIEA (0.6 mL, 3.44 mmol) and DMSO (1 mL) was heated to 130 C. for 30 min in a Biotage Initiator microwave oven. The reaction mixture was injected on a preparative HPLC UV using a high pH shallow gradient method (Mobile phase: 30-50% B; A: H2O with 15 mM NH4CO3 and 0.375% NH4OH v/v, B: CH3CN, 30 min. run) on XBridge Prep C18 OBD, 30¡Á150 mm, 10 mum, Waters reverse phase column, to provide title compound (76 mg, 59.9%) as a solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.59-1.68 (m, 2H) 1.68-1.82 (m, 4H) 1.91 (br. s., 2H) 1.99-2.12 (m, 4H) 2.13-2.24 (m, 2H) 2.30 (br. s., 4H) 2.74 (quin, J=7.52 Hz, 1H) 3.22 (quin, J=8.69 Hz, 1H) 3.39 (br. s., 2H) 3.45-3.53 (m, 2H) 3.54-3.62 (m, 2H) 3.65 (br. s., 2H) 7.79 (d, J=2.34 Hz, 1H) 8.03 (dd, J=2.73, 1.56 Hz, 1H) 8.14 (s, 1H); HRMS m/z calcd for C21H32N5O 370.2601 [M+H]+, found 370.2604.
The synthetic route of 4949-13-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; US2010/130477; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem