Synthetic Route of 186534-02-1,Some common heterocyclic compound, 186534-02-1, name is 3,5,6-Trimethylpyrazine-2-carbaldehyde, molecular formula is C8H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5.5 g (36.7 mmol) of compound 1a-4The sample was dissolved in 30 ml of formic acid.Weigh 3.2g (45.9mmol)Hydroxylamine hydrochloride was added, followed by 3.13 g (45.9 mmol)Sodium formate, miscible, 120 C oil bath reaction reflux overnight.The pH of the reaction mixture was adjusted to 10 with a saturated aqueous sodium hydroxide solution and extracted with dichloromethane (30 ml*5 times). 100-200 mesh silica gel sample, dry sample column chromatography:Mobile phase EA: PE (1:5), TLC monitors the fraction of the effluent fraction,The compound 1a-5 fraction was collected. Combine the same fraction and distill dry,White solidCompound 1a-5, yield 65%.
The synthetic route of 186534-02-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Xique Pharmaceutical Co., Ltd.; Wang Yuqiang; Yao Hui; Wu Chuanbin; Tao Liang; Sun Yewei; (27 pag.)CN103804309; (2019); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem