Electric Literature of 19745-07-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19745-07-4 as follows.
Step C: A flask was charged with (S)-3-(2,6-difluoro-4-(methylsulfonyl)phenylamino)-l,4′-bipiperidin-2-one hydrochloride (0.250 g, 0.590 mmol), 2,5-dichloropyrazine (0.105 g, 0.708 mmol), Hunig’s base (0.309 mL, 1.77 mmol), and DMF (5 mL). The reaction mixture was stirred at 100 ¡ãC overnight. The organic solvents were removed under reduced pressure. The residue was purified using silica gel column chromatography eluting with ethyl acetate to provide (S)-l’-(5-chloropyrazin-2-yl)-3-(2,6- difluoro-4-(methylsulfonyl)phenylamino)-[l,4′-bipiperidin]-2-one (0.102 g, 0.204 mmol, 34.6percent yield) as light yellow solid. Mass spectrum (apci) m/z = 500.1 (M+H).
According to the analysis of related databases, 19745-07-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARRAY BIOPHARMA INC.; AICHER, Thomas Daniel; BENCSIK, Josef Roland; BOYD, Steven Armen; CONDROSKI, Kevin Ronald; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald Jay; PRATT, Scott Alan; SINGH, Ajay; TURNER, Timothy M.; WO2011/146335; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem