In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59303-10-5, name is 2-Chloro-5-methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2-Chloro-5-methylpyrazine
Example 8l-((2S,4R)-6-(l-(2-methoxyethyl)-lH-pyrazol-4-yl)-2-methyl-4-((5- methylpyrazin-2-yl)amino)-3, -dihydroquinolin-l(2H)-yl)ethanonel-((2S,4R)-4-Amino-6-(l-(2-methoxyethyl)-lH-pyrazol-4-yl)-2-methyl-3,4- dihydroquinolin-l(2H)-yl)ethanone (for a preparation see Intermediate 7) (150mg, 0.457 mmol), 2-chloro-5-methylpyrazine (147mg, 1.142 mmol), Davephos (71.9mg, 0.183 mmol), Pd2(dba)3 (84mg, 0.091 mmol) and sodium tert-butoxide (132mg, 1.370 mmol) were combined in 1,4-dioxane (4ml) and the mixture heated at 120C for 25min (microwave). The reaction mixture was partitioned between water (75ml) and DCM (3x 75ml). The organics were combined, dried (hydrophobic frit) and evaporated under vacuum. The resulting brown oil was dissolved in DMSO (3x 1ml) and purified by MDAP (formate x3). The solvent was evaporated under vacuum to give l-((2S,4R)-6-(l-(2-methoxyethyl)-lH-pyrazol-4-yl)-2- methyl-4-((5-methylpyrazin-2-yl)amino)-3,4-dihydroquinolin-l(2H)-yl)ethanone (91mg, 0.216 mmol, 47 % yield) as a yellow glass. LCMS (formate), Rt 0.75min, MH+ 421.
The synthetic route of 59303-10-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE LLC; AMANS, Dominique; DEMONT, Emmanuel, Hubert; JONES, Katherine, Louise; SEAL, Jonathan, Thomas; WALKER, Ann, Louise; WO2012/150234; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem