Adding a certain compound to certain chemical reactions, such as: 1209459-10-8, name is 2-Bromo-5-fluoropyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1209459-10-8, COA of Formula: C4H2BrFN2
(R)-N-(6-(1-(1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-1H-tetrazol-5-yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide (97 mg, 0.185 mmol), 2-bromo-5-fluoropyrazine (49.2 mg, 0.278 mmol), RuPhos (17.29 mg, 0.037 mmol), Pd(dba)2 (10.65 mg, 0.019 mmol) and Cs2CO3 (121 mg, 0.370 mmol) were combined in a vial. Toluene (0.842 ml) was added and the mixture was evacuated and back-filled with N2 three times. Heated under N2 at 80 C. overnight. The reaction was filtered through celite, rinsing with EtOAc. The filtrate was concentrated to give an orange gum. The crude sample was treated with conc. HCl/MeOH (1:10, 3 mL) at rt until the TBS group was cleaved. After concentration, the crude sample was purified by preparative HPLC (10% ACN/water to 90% ACN/water in ?40 min with 0.1% FA buffer) to give (R)-2-(5-fluoropyrazine-2-yl)-N-(6-(1-(1-hydroxypropan-2-yl)-1H-tetrazol-5-yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide (6 mg, 0.012 mmol, 6% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-5-fluoropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Enanta Pharmaceuticals, Inc.; Granger, Brett; Wang, Guoqiang; Shen, Ruichao; He, Jing; He, Yong; Xing, Xuechao; Ma, Jun; Long, Jiang; Wang, Bin; Or, Yat Sun; (121 pag.)US2020/157095; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem