Synthetic Route of 63744-22-9,Some common heterocyclic compound, 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a 250-mL 3 -necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, were placed 6,8-dibromoimidazo[l,2-a]pyrazine (5 g, 18.06 mmol, 1.00 equiv) and /V, /V-di methyl formam i dc (125 mL). This was followed by the addition of (0249) NIS (4.3 g, 19.11 mmol, 1.05 equiv), in portions at room temperature. The resulting solution was stirred overnight at 60 C in an oil bath. The reaction mixture was cooled to room temperature with a water/ice bath and then quenched with water. The resulting solution was extracted with ethyl acetate and the organic layers combined and concentrated under vacuum. Purification by flash chromatography (silica gel column with ethyl (0250) acetate/petroleum ether (1/2)) provided 2.8 g (38%) of 5-1 as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6,8-Dibromoimidazo[1,2-a]pyrazine, its application will become more common.
Reference:
Patent; IDEAYA BIOSCIENCES, INC.; BECK, Hilary, Plake; GONZALEZ-LOPEZ, Marcos; SUTTON, James, Clifford, Jr.; (86 pag.)WO2019/156989; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem