Application of 1245644-42-1,Some common heterocyclic compound, 1245644-42-1, name is 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, molecular formula is C6H3BrIN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: [0199] A suspension of tributyl(R2)stanne (3.11 mmol), 6-bromo-3-iodo-imidazo[1,2-a]pyrazine 17* (3.11 mmol) andPd(PPh3)4 (0.93 mmol) in dioxane (20 mL) was heated to 150 C in a microwave tube for 20 minutes. The resultingmixture was filtered through celite and evaporated under reduced pressure. If necessary, the reaction was then carriedout more times on the same scale. The crude products were combined and purified by flash chromatography to give theintermediate 18*.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Bromo-3-iodoimidazo[1,2-a]pyrazine, its application will become more common.
Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem