Some common heterocyclic compound, 32111-28-7, name is N-Methylpyrazin-2-amine, molecular formula is C5H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 32111-28-7
To a stirred solution of N-methylpyrazin-2-amine (1 g, 9.2 mmol) in dimethyl sulfoxide (20 ml) / water (0.4 ml) at 10 C was added portionwise N-lodosuccinimide (4.1 g, 18.4 mmol). The reaction mixture was then allowed to warm slowly to room temperature and stirred at that temperature overnight. An additonal aliquot of N-lodosuccinimide (4.1 g,18.4 mmol) was then added at room temperature. After stirring for 7hr, the reaction mixture was poured onto ice (20 g). The precipitate was collected, washed with cold water (20 ml), and dried to provide the title compound (2.15 g, 65 %). 1H NMR (300MHz, DMSO-d6) 5(ppm): 8.14(s, 1 H), 6.69 (br, 1 H), 2.77(d, 3 H, J=4.5 Hz); ESI-MS(-):360.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 32111-28-7, its application will become more common.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; MUEHLEBACH, Michel; STOLLER, Andre; LOISELEUR, Olivier; BUCHHOLZ, Anke; HUETER, Ottmar Franz; BIGOT, Aurelien; HALL, Roger Graham; EMERY, Daniel; JUNG, Pierre Joseph Marcel; LU, Long; WU, Yaming; CHEN, Ruifang; WO2015/715; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem