Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74290-67-8, name is 2-Amino-5-bromo-3-methylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
Example 110 N-(3-((5-amino-6-methylpyrazin-2-yl)ethynyl)-2,4-difluorophenyl)-5-chloro-2-methoxypyridine-3-sulfonamide A mixture of 5-chloro-N-(3-ethynyl-2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide (108 mg), 2-amino-5-bromo-3-methylpyrazine (54 mg), dichlorobis(tricyclohexylphosphine)palladium(II) (11 mg), cesium carbonate (290 mg) and DMSO (2 mL) was stirred under microwave irradiation at 120 C. for 2 hr. After cooling to room temperature, the reaction mixture was purified by silica gel column chromatography (ethyl acetate/hexane) and further purified by HPLC (C18, mobile phase: water/acetonitrile (0.1% TFA-containing system)). Fractions containing the object product were collected, neutralized with a saturated aqueous sodium hydrogen carbonate solution and extracted 2 times with ethyl acetate. The obtained organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated to give a residue. The residue was washed with ethyl acetate/IPE and dried under reduced pressure to give the title compound (63 mg). 1H NMR (300 MHz, DMSO-d6) delta 2.30 (3H, s), 3.93 (3H, s), 6.86 (2H, s), 7.10-7.23 (1H, m), 7.32 (1H, td, J=8.9, 6.0 Hz), 8.04 (1H, s), 8.06 (1H, d, J=2.5 Hz), 8.49 (1H, d, J=2.6 Hz), 10.46 (1H, s).
According to the analysis of related databases, 74290-67-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Takeda Pharmaceutical Company Limited; FUJIMOTO, Jun; LIU, Xin; KURASAWA, Osamu; TAKAGI, Terufumi; CARY, Douglas Robert; BANNO, Hiroshi; ASANO, Yasutomi; KOJIMA, Takuto; (159 pag.)US2019/169166; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem