Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5049-61-6, name is Pyrazin-2-amine, A new synthetic method of this compound is introduced below., Quality Control of Pyrazin-2-amine
2-Aminopyrazine (0.50 g, 5.26 mmol) was dissolved in THF (50 mL), and N-chlorosuccinimide (1.62 g, 12.1 mmol) was added to the solution with stirring. The mixture was refluxed at 100 C for 10 h. After cooling, solvent was evaporated. The residue was directly purified by column chromatography. Finally, the obtained product was washed with pentane/diethyl ether (5:1) to 2-Amino-3,5-dichloropyrazine 1b (492 mg, 57%) as a slightly yellow solid. 1H NMR (200 MHz, CDCl3) delta 7.99 (s, 1H), 5.10 (br, 2H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kwak, Se Hun; Lee, Gee-Hyung; Gong, Young-Dae; Bulletin of the Korean Chemical Society; vol. 33; 12; (2012); p. 4271 – 4274;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem